LeHavreV1, France, Analysis, bibRecord, 001732

Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.

Identifieur interne : 001732 ( France/Analysis ); précédent : 001731; suivant : 001733

Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.

Auteurs : Jean-Pierre Goullé [France] ; Pascal Le Roux [France] ; Mireille Castanet [France] ; Loïc Mahieu [France] ; Stéphanie Guyet-Job [France] ; Michel Guerbet [France]

Source :

Journal of analytical toxicology [ 1945-2403 ]

RBID : pubmed:26265286

English descriptors

KwdEn :
- Adolescent, Blood Chemical Analysis, Child, Child, Preschool, Female, Forensic Toxicology (methods), Humans, Male, Metals, Heavy (blood), Plasma (chemistry), Reference Values, Spectrophotometry, Atomic.
MESH :
- chemical , blood : Metals, Heavy.
- chemistry : Plasma.
- methods : Forensic Toxicology.
- Adolescent, Blood Chemical Analysis, Child, Child, Preschool, Female, Humans, Male, Reference Values, Spectrophotometry, Atomic.

Abstract

In recent years, special emphasis has been put on heavy metals. Children are very sensitive to accumulation of metals. Furthermore, as regards elements, the reference values in children are scarce in the literature as it is difficult to obtain the large quantity of blood necessary to analyze many metals by the conventional atomic absorption spectrometry technique. An inductively coupled plasma mass spectrometry (ICP-MS) procedure that uses a reduced sample of 0.3 mL whole blood or plasma is adapted to multielemental determinations. We applied a previously validated technique for adults that simultaneously quantifies 25 elements by ICP-MS in whole blood and 23 in plasma in a series of 99 healthy children ranging from under 5 years to <18 years, without exposure to metal or drug-containing metals. The aims of the study were to compare metallic concentrations according to the age among children and metallic concentration differences between children and adults. The blood and plasma pediatric metallic profile is a practical useful tool for many purposes in clinical toxicology, forensic toxicology and any cases of metal environmental exposure.

DOI: 10.1093/jat/bkv088
PubMed: 26265286

Affiliations:

Links to Exploration step

pubmed:26265286

Le document en format XML

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<author><name sortKey="Guyet Job, Stephanie" sort="Guyet Job, Stephanie" uniqKey="Guyet Job S" first="Stéphanie" last="Guyet-Job">Stéphanie Guyet-Job</name>
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<term>Forensic Toxicology (methods)</term>
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<front><div type="abstract" xml:lang="en">In recent years, special emphasis has been put on heavy metals. Children are very sensitive to accumulation of metals. Furthermore, as regards elements, the reference values in children are scarce in the literature as it is difficult to obtain the large quantity of blood necessary to analyze many metals by the conventional atomic absorption spectrometry technique. An inductively coupled plasma mass spectrometry (ICP-MS) procedure that uses a reduced sample of 0.3 mL whole blood or plasma is adapted to multielemental determinations. We applied a previously validated technique for adults that simultaneously quantifies 25 elements by ICP-MS in whole blood and 23 in plasma in a series of 99 healthy children ranging from under 5 years to <18 years, without exposure to metal or drug-containing metals. The aims of the study were to compare metallic concentrations according to the age among children and metallic concentration differences between children and adults. The blood and plasma pediatric metallic profile is a practical useful tool for many purposes in clinical toxicology, forensic toxicology and any cases of metal environmental exposure.</div>
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<name sortKey="Castanet, Mireille" sort="Castanet, Mireille" uniqKey="Castanet M" first="Mireille" last="Castanet">Mireille Castanet</name>
<name sortKey="Guerbet, Michel" sort="Guerbet, Michel" uniqKey="Guerbet M" first="Michel" last="Guerbet">Michel Guerbet</name>
<name sortKey="Guyet Job, Stephanie" sort="Guyet Job, Stephanie" uniqKey="Guyet Job S" first="Stéphanie" last="Guyet-Job">Stéphanie Guyet-Job</name>
<name sortKey="Le Roux, Pascal" sort="Le Roux, Pascal" uniqKey="Le Roux P" first="Pascal" last="Le Roux">Pascal Le Roux</name>
<name sortKey="Mahieu, Loic" sort="Mahieu, Loic" uniqKey="Mahieu L" first="Loïc" last="Mahieu">Loïc Mahieu</name>
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Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.

Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children.

Source :

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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